It is our great pleasure to invite you to submit papers and attend the 20th International Conference on Intelligent Systems and Knowledge Engineering (ISKE 2025), which will be held in Shunde, China during November 21-23, 2025. ISKE 2025 is the 20th in a series following the successful previous ISKE Conferences since 2006. ISKE 2025 is organized by Shunde Polytechnic, China.